Annual Reports in Medicinal Chemistry, 4 by C K Cain

By C K Cain


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A. C. P r z y b y E and S. C. Wang, J. Pharmacol. E x p t l . Therap. 163(2), 439 (1968). 12, - - - 17, - - - 36 - Sect. I - CNS Agents C h i l d r e s s , Ed. 30, R. Clark, T. E. Lynes, W. A. Price, J. P. Marvel, D. H. Smith and V. G. Vernier, Pharmacologist 10(2), 197 (1968). 31. M. Levine, P. B. Jossmann, D. G. Friend and V, DeAngeli , C l i n . Pharmacol. Therap. 9(4), 448 (1968). 32. M. S. Chodnekar and-J. E. Blum, J. Med. Chem. 11(5), 1023 (1968). Med. Chem. fl(4), 33. F. B o t t a r i , M.

Low doses may cause p e r i p h e r a l v a s o d i l a t i o n only, while higher doses a l s o decrease c a r d i a c o u t p u t . Excessive doses re$uce c a r d i a c o u t p u t without changing p e r i p h e r a l r e s i s t a n c e . * I n cases of poor cont r o l w i t h ST 155 a l o n e , combination w i t h methyldopa o r guanethidine gave good r e s u l t s without o r t h o s t a t i c o r r e n a l problems ? - Methyldopa Strong evidence f o r a c e n t r a l mechanism of a c t i o n w a s r e p o r t e d t 6 Pretreatment w i t h R0-4-4602, (N1-DLseryl-N-2,3,4-trihydroxybenzylhydrazine) a c e n t r a l and peri p h e r a l decarboxylase i n h i b i t o r , completely i n h i b i t e d t h e 48 - Sect.

Saettone and M. F. S e r a f i n i ,J, 904 (1968). 34. R. B. M o f f e t t , J. Med. Chem. 11(6), 1251 (1968). 35. Y. M. B a t u l i n , V. T. Klimko, A. Klygul, N. E. Chupiianova, Y. V i k h l i a e v and A. P. Sholdinov, Med. Prom. SSSR(2), 3 (1968). 36. R. D. H o l l i f i e l d and J. D. Conklin, Arch. I n t e r n . Pharmacodyn. 174(2), 333 (1968). 37. H. R. , C. S. Davis, R. K. Bickerton and R. P. H a l l i d a y , J. Med. Chem. 10(5), 807 (1967). 38. E. Lear, A n e s t k i a Analgesia, Current Res.

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