Basic Pharmacokinetics by Sunil S. Jambhekar, Philip J. Breen

By Sunil S. Jambhekar, Philip J. Breen

Uncomplicated Pharmacokinetics offers an knowing of the foundations of pharmacokinetics and biopharmaceutics and of the way those ideas could be utilized to accomplish winning drug treatment.

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5 Method for creating profiles (sketches) 1 You will be asked to sketch A versus B (A as a function of B). When presented in this form, the convention is that A is the y-axis variable (the dependent variable) and B is the x-axis variable (the independent variable). For example: Sketch: τ vs (Cp )∞ ↑ ↑ y x 2 Next, you will need to (find and) apply the appropriate equation containing the y and x variables you have been asked to sketch. For this example, the equation is (Cp )∞ = SFX0 VKτ Note that we do not have to know the pharmacokinetic interpretation of the symbols at this point.

Answer: when it is a parameter. 2 When is a constant not a constant? Answer: when it is a parameter. The answers to these questions suggest that a parameter is something between a variable and a constant. This is approximately true; but the very specific meaning of “parameter” in pharmacokinetics is as follows: A parameter is a number that is characteristic (and constant) for a specific patient receiving a specific drug. A couple of examples of pharmacokinetic parameters are elimination half life (the time it takes for a plasma drug concentration to drop to half its original value) and apparent volume of distribution (the volume to which a given dose of drug would have to be diluted in order to have a concentration equal to that concentration detected in the blood).

Months) or if a disease or drug interaction has occurred since the value was last calculated. For most pharmacokinetic calculations in this text, we will concern ourselves with a single subject or patient receiving a particular drug; therefore, the parameter will be a constant under those particular circumstances. 2 expands on the subject of pharmacokinetic parameters. 2 Parameters 1 When is a variable not a variable? Answer: when it is a parameter. 2 When is a constant not a constant? Answer: when it is a parameter.

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