Biodrug Delivery Systems: Fundamentals, Applications and by Mariko Morishita, Kinam Park

By Mariko Morishita, Kinam Park

Biodrug supply structures: basics, purposes and medical Development provides the paintings of a world staff of top specialists in drug improvement and biopharmaceutical technology who talk about the newest advances in biodrug supply structures and linked ideas. The booklet discusses elements of winning formula, supply, and construction of biodrugs, which come with subtle crops and intricate tactics, a well-trained and an expert employees, and correct qc. additionally, the authors examine:

  • ADME (Absorption, Metabolism, Distribution, and removal of biodrugs)
  • Directing and influencing the winning improvement of at the moment advertised best-selling biodrugs
  • Routes of management
  • Mechanisms of biodrug absorption
  • Alternative chances for drug supply routes
  • Formulationson the industry from the point of view of group of workers concerned about biodrug development

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Additional info for Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development (Drugs and the Pharmaceutical Sciences)

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Effect of surfactants on the physical stability of recombinant human growth hormone. J Pharm Sci 1995; 84(6):713–716. 24 Jørgensen et al. 37. Dong A, Prestrelski SJ, Allison SD, et al. Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation. J Pharm Sci 1995; 84 (4):415–424. 38. Treuheit MJ, Kosky AA, Brems DN. Inverse relationship of protein concentration and aggregation. Pharm Res 2002; 19(4):511–516. 39. Vestergaard B, Groenning M, Roessle M, et al. A helical structural nucleus in hte primary elongating unit of insulin amyloid fibrils.

Proteins at interfaces: principles, multivariate aspects, protein resistant surfaces, and direct imaging and manipulation of adsorbed proteins. Clin Mater 1992; 11(1–4):67–84. 43. Cheesman DF, Davies JT. Physiochemical and biological aspects of proteins at interfaces. Adv Protein Chem 1954; 9:439–501. 44. Norde W, Giacomelli CE. BSA structural changes during homomolecular exchange between the adsorbed and the dissolved states. J Biotechnol 2000; 79(3):259–268. 45. Green RJ, Hopkinson I, Jones RAL.

Preservation of the structural integrity of the therapeutic protein is essential with respect to maintaining the biological activity and avoiding unwanted 16 Jørgensen et al. TABLE 2 Major Degradation Pathways for Peptides and Proteins Physical degradation Chemical degradation Denaturation Aggregation Fibrillation Precipitation Adsorption Hydrolysis Oxidation Racemization Isomerization b-Elimination Deamidation Disulfide exchange Photodegradation immunological reactions (16–19). Hence, the major challenges in the development of pharmaceutical formulations are both to avoid unwanted changes in the structure and to understand the processes and formulation parameters that affect the stability.

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