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Zharov et al. (2003) performed similar studies on the photothermal destruction of K562 cancer cells. Photothermal properties of Au nanoparticles of different shapes and structures were reviewed in a recent review (Huang and Al-Sayed, 2010). Compared with nanoshells, the use of Au nanorods enables effective treatment at three times lower laser intensity. , 2006a). , 2008). In photothermal therapy, a cw Ti:Sapphire laser at 800 nm, overlapping maximally with the SPR absorption band of the nanorods, was used for electromagnetic irradiation of labeled cells.
Skin cancer). Tissue absorbs light in the visible region and infrared (IR) light can only penetrate relatively thin tissue. , 2007). The light penetration depth can be up to a few centimeters in the spectral region 650–900 nm, also known as the biological NIR window, depending on the tissue type (Weissleder, 2001). , 2003). 5 J/cm2 with a heat fluid layer of 15 nm. Cell death is attributed mainly to the cavitation damage induced by the generated micro-scale bubbles around the nanoparticles. Zharov et al.
2006a,b). An improvement of cancer imaging based on the scattering properties of Au nanoparticles was made by El-Sayed et al. , 2005). In this case, the nanoparticles are excited by white light from a halogen lamp, which is also the same lamp used for bright field imaging. 3a and b), a dark field condenser delivers and focuses a very narrow beam of white light on the top of the sample with the center illumination light blocked by the aperture. The objective with an iris for adjusting the light collection zone is used to collect only the scattered light from the samples and thus presents an image of a bright object in a dark background.