Biomaterials from nature for advanced devices and therapies by Nuno M. Neves, Rui L. Reis

By Nuno M. Neves, Rui L. Reis

In-depth details on usual biomaterials and their purposes for translational medicine!

  • Undiluted services: edited by means of world-leading specialists with contributions from top-notch overseas scientists, collating adventure and state-of-the-art wisdom on average biomaterials from all around the world
  • A must-have at the shelf in each biomaterials lab: graduate and PhD scholars starting their profession in biomaterials technology and skilled researchers and practitioners alike will flip to this finished reference of their day-by-day work
  • Link to scientific perform: chapters on translational study make readers conscious of what has to be thought of while a biomaterial leaves the lab to be oftentimes used

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Solubility, denaturation temperature) compared to the cold water species, demineralization methods cannot be the same. To extract collagen from this type of raw materials, it is necessary to first remove its mineral content. 5 M) [44]. Its effectiveness is dependent on the concentration and time of reaction. Demineralized bone, that is 20 MARINE COLLAGEN ENVISAGING BIOMEDICAL APPLICATION called ossein, can now proceed to the next extraction phase. The demineralization process with EDTA is also applied to cartilages [24] and scales [45].

2 Photograph (a) and SEM photomicrographs (b, c) of top surface (b) and crosssection (c) of funnel-like collagen sponge prepared with 398 μm-diameter ice particulate template at –3◦ C. Adapted and reproduced from Ref. 1177/0883911510370002). For a color version of this figure, see the color plate section. 6 COLLAGEN-BASED POROUS SCAFFOLDS FOR TISSUE ENGINEERING ice particulates which are used as templates because the large surface pores should be the replicas of the embossing ice particulates. The underlying bulk pores are interconnected with the large surface pores and extend into the bulk body of the sponge from the surface pores.

Fast freezing at a lower temperature induces cracking, uniform small channels and formation of a fibrous structure. Slow freezing at a higher temperature results in nonuniformity and large pores with more collapsed pores than continuous channels. A unidirectional freezing-drying method has been developed to prepare unidirectionally structured collagen sponge [17]. Collagen sponge resembling the extracellular matrix structure of a particular tissue has been prepared by specific freezing regimes [18].

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