Biomedical Applications of Proteomics by Jean-Charles Sanchez, Garry L. Corthals, Denis F.

By Jean-Charles Sanchez, Garry L. Corthals, Denis F. Hochstrasser

Content material:
Chapter 1 Proteomics in Biomedicine – a device, a technology, or an paintings? (pages 5–15): Prof. Marc A. Reymond
Chapter 2 Antibody?Based Vascular concentrating on: Proteomic options for the identity and Quantification of Membrane Proteins on Endothelial Cells (pages 17–38): Simone Scheurer, Jascha?Nikolai Rybak, Christoph Roesli, Dr. Giuliano Elia and Prof. Dr. Dario Neri
Chapter three Vasculature, Vascular sickness, and Atherosclerosis (pages 39–55): Elisabetta Gianazza and Ivano Eberini
Chapter four Discovery of latest Diagnostic Markers of Stroke (pages 57–72): Dr. Laure Allard, Prof. Dr. Denis F. Hochstrasser and Dr. Jean?Charles Sanchez
Chapter five Unravelling organic Pathways and the identity of scientific Markers and ambitions in Renal melanoma (pages 73–96): Rosamonde E. Banks and Peter J. Selby
Chapter 6 warmth surprise Protein 27 in melanoma (pages 97–109): Dr. Cecilia Sarto, Dr. Fulvio Magni, BS. Cristina Valsecchi and Prof. Dr. Paolo Mocarelli
Chapter 7 Proteomic methods for Biomarker Discovery in Colorectal melanoma (pages 111–131): Prof. Dr. Richard J. Simpson and Dr. Donna S. Dorow
Chapter eight medical Proteomics: Ovarian melanoma (pages 133–154): Prof. Dr. Ayodele A. Alaiya
Chapter nine Protein Expression Profiling research in Hematopoietic Stem Cells: Phenotypic Characterization of Mesenchymal Stem Cells (pages 155–171): Dr. Juan Antonio Lopez, Dr. Antonio Bernad and Dr. Juan Pablo Albar
Chapter 10 Lymphoblastoid and Lymphoma Cells (pages 173–188): Dr. Raymonde Joubert?Caron, Dr. Didier Lutomski and Dr. Michel Caron
Chapter eleven Chemoresistance in melanoma Cells (pages 189–204): Dr. Julia Poland, Prof. Dr. Dirk Schadendorf, Dr. Hermann Lage and Prof. Dr. Pranav Sinha
Chapter 12 Diabetes Mellitus: advanced Molecular adjustments (pages 205–223): Gerhard Schmid and Dr. Jean?Charles Sanchez
Chapter thirteen Proteome method of Infectious ailments: Acute?Phase Proteins and Antibody Profiles as Diagnostic signs in Human Plasma (pages 225–243): Dr. Luca Bini, Dr. Sabrina Liberatori and Prof. Dr. Vitaliano Pallini
Chapter 14 Proteomic stories of Human Lymphocytes: New Insights into HIV Lymphocyte an infection? (pages 245–262): Dr. Francoise Vuadens, David Crettaz, Amalio Telenti, Dr. Manfredo Quadroni, Michel A. Duchosal, Prof. Dr. Philippe Schneider and Prof. Dr. Jean?Daniel Tissot
Chapter 15 differences of Host telephone Proteome caused by way of Herpes Simplex Virus variety 1 (pages 263–283): Dr. Anna Greco, Dr. Yohann Coute, Dr. Stephane Giraud and Dr. Jean?Jacques Diaz
Chapter sixteen Francisella Tularensis (pages 285–313): Dr. Jiri Stulik, Martin Hubalek, Lenka Hernychova, Jana Havlasova, Juraj Lenco, Ales Macela, Igor Golovliov and Anders Sjostedt
Chapter 17 Proteomics in medical Neuroscience (pages 315–340): Pierre R. Burkhard and Dr. Jean?Charles Sanchez
Chapter 18 Human Cerebrospinal Fluid (pages 341–353): Dr. Pia Davidsson and Dr. Michael G. Harrington
Chapter 19 Proteomic functions for Molecular review of Alzheimer's disorder (pages 355–370): Dr. Odile Carrette, Pierre R. Burkhard, Prof. Dr. Denis F. Hochstrasser and Dr. Jean?Charles Sanchez
Chapter 20 MALDI?MS Imaging in Biomedical learn (pages 371–388): Dr. Markus Stoeckli and Dr. Terry B. Farmer
Chapter 21 Protein diversifications: assets and instruments (pages 389–422): Dr. Yum Lina Yip, Dr. Maria Livia Famiglietti, Elisabeth Gasteiger and Prof. Dr. Amos Bairoch

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Markers for angiogenesis located on the cell surface of tumor endothelial cells are the integrins avb3 [52, 53], endoglin [54], VEGF and VEGF receptor complex [55], prostate-specific membrane antigen (PSMA) [56], aminopeptidase N [57], CD62E [58], and also phosphatidylserine phospholipids [59]. By using serial analysis of gene expression, novel genes (TEM1, TEM5, and TEM8), encoding tumor endothelial markers have been found [51, 60]. Other markers of angiogenesis are part of the modified ECM. Probably one of the most selective markers of angiogenesis, the extra domain B of fibronectin (ED-B), is located in the modified ECM within the tumor environ- 23 24 2 Antibody-based Vascular Targeting ment [48, 49].

12 Further Reading alized, impersonal scientific knowledge to a singular, individual, personalized practice. Since proteomics analyze the functional molecules of a normal or diseased cell, and because proteomics take into account dynamic aspects over time, it is expected that this novel science will make a major contribution to the development of medical art. By analyzing tissues of human origin, linking disease and/or risk-specific molecular patterns with patient identity, the researcher is endorsing potential risks, linked to protection of privacy, violation of existing or future legislation, unauthorized or unethical use of samples, financial claims on research results, non-communication of prognostic information of potential risks, etc.

Hochstrasser Copyright © 2004 Wiley-VCH Verlag GmbH & Co. 1 Introduction Cancer chemotherapy relies on the expectation that anticancer drugs will preferentially kill rapidly dividing tumor cells, rather than normal cells. Since a large proportion of the tumor cells have to be killed in order to obtain and maintain a complete remission, large doses of drugs are typically used, with significant toxicity towards proliferating non-malignant cells. e. the doses of drug which are required to kill tumor cells cause unacceptable toxicities to normal tissues).

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