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We propose using large-scale association studies (of the transmission disequilibrium design) to identify alleles conferring increased risk for bipolar disease. This approach is complementary to linkage analyses and takes advantage of data from linkage analyses. We hypothesize that certain areas which have yielded linkage signals in three or more whole genome scans may harbor disease alleles of moderate individual impact, but of large potential population impact. Thus, we will focus on genes/SNPs from these areas.
If 03FA are indeed effective mood stabilizers for bipolar disorder, this project would provide additional evidence of aberrant signal transduction mechanisms in the pathophysiology of bipolar disorder, and may herald the advent of a new class of rationally designed mood stabilizing drugs. Generate_Screen • Project Title: PHARMACOTHERAPY OF HIGH-RISK BIPOLAR DISORDER Principal Investigator & Institution: Oquendo, Maria A. Associate Clinical Professor; New York State Psychiatric Institute 1051 Riverside Dr New York, Ny 10032 Timing: Fiscal Year 2001; Project Start 1-SEP-2000; Project End 0-JUN-2005 Summary: (Adapted from the Applicant's Abstract): This R01 application, based at New York State Psychiatric Institute (NYPSI) requests five years of support for a prospective, parallel group, double blind, random assignment treatment study of high-risk (previous suicide attempters) patients with Bipolar Disorder, who are in a mixed or depressed phase.
But first we need a better understanding of the causes of disability and the services currently being provided. Generate_Screen Studies 37 • Project Title: TRANSCRANIAL MAGNETIC STIMULATION IN BIPOLAR DISORDER Principal Investigator & Institution: Pascual-Leone, Alvaro; Associate Professor; Beth Israel Deaconess Medical Center E/Es-214 Boston, Ma 02215 Timing: Fiscal Year 2001 Summary: This abstract is not available.