British National Formulary (BNF) 68 by Pharmaceutical Press

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Extra info for British National Formulary (BNF) 68

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Www. org Important During the second and third trimesters drugs can affect the growth or functional development of the fetus, or they can have toxic effects on fetal tissues. Drugs given shortly before term or during labour can have adverse effects on labour or on the neonate after delivery. The BNF identifies drugs which: . may have harmful effects in pregnancy and indicates the trimester of risk . 00–17:00 Monday to Friday; urgent enquiries only outside these hours). The information is based on human data, but information from animal studies has been included for some drugs when its omission might be misleading.

Hyoscine butylbromide is used for bowel colic and for excessive respiratory secretions, and is less sedative than hyoscine hydrobromide. Hyoscine butylbromide is given in a subcutaneous infusion dose of 60–300 mg/ 24 hours for bowel colic and 20–120 mg/24 hours for excessive respiratory secretions (important: these doses of hyoscine butylbromide must not be confused with the much lower dose of hyoscine hydrobromide, above). 2 mg/24 hours by subcutaneous infusion may also be used to treat bowel colic or excessive respiratory secretions.

1). 1) can be tried. Constipation Hypercalcaemia Constipation is a common cause of distress and is almost invariable after administration of an opioid analgesic. g. 3). 6) is licensed for the treatment of opioidinduced constipation. Convulsions Patients with cerebral tumours or uraemia may be susceptible to convulsions. 1) should be considered. When oral medication is no longer possible, diazepam as suppositories 10–20 mg every 4 to 8 hours, or phenobarbital by injection 50– 200 mg twice daily is continued as prophylaxis.

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