By Yves Chapleur
Carbohydrate Chemistry and Glycobiology have witnessed a fast growth over the last few years with the improvement of diverse new, ingenious and effective syntheses which offer extra perception into constructions and organic interactions of glycoconjugates. Glycosylation reactions are accepted within the synthesis of prescribed drugs and bio-active compounds. In biology and drugs oligosaccharides play a primary function in immuno-stimulation, melanoma or allergic responses. Glycoscience is a truly instructive instance of the way one universal subject of curiosity stimulates either chemistry and biology to jointly open clinical frontiers.This synergy is made obvious during this paintings. 3 top specialists within the fields of Glycochemistry and Glycobiology have invited quite a few well known authors to supply a entire assessment of the hot advances and findings in Glycoscience. This four-volume guide offers an built-in and state of the art view, and covers all chemical elements, similar to syntheses and research of carbohydrates and oligosaccharides, in addition to the organic position and task of oligosaccharides and carbohydrate/protein interactions.
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Extra info for Carbohydrate Mimics: Concepts and Methods
Sample text
Glycogen Synthase and the Bulk Synthesis of Glycogen ........... Properties ............................................................ Structure of Glycogen Synthase ..................................... Branching Enzyme .................................................. Intermediates in the Biosynthesis of Glycogen ..................... 6 Conclusion ........................................................... Acknowledgments ................................................... References ............................................................
Laurent Introduction .......................................................... Site of Biosynthesis .................................................. Biosynthetic Precursors .............................................. Hyaluronan Synthases ............................................... Microbial Enzymes .................................................. Vertebrate Synthases ................................................. Mechanism of Synthesis .............................................
General Features .................................................... Carbohydrate Digestion ............................................. Protein and Linkage Hydrolysis .................................... Formation of Thyroid Hormone via Lysosomal Degradation of Thyroglobulin ....................................................... Synthesis of Thyroid Hormone ..................................... Carbohydrate Degradation .......................................... Proteolysis ...........................................................