By James A. Dykens, Yvonne Will
This is often the definitive, one-stop source on preclinical drug review for power mitochondrial toxicity, addressing the difficulty in advance within the drug improvement procedure. It discusses mitochondrial impairment to organs, skeletal muscle, and anxious structures and information methodologies used to evaluate mitochondria functionality. It covers either in vitro and in vivo equipment for research and contains the newest versions. this can be the authoritative reference on drug-induced mitochondrial disorder for safeguard overview execs within the pharmaceutical and for pharmacologists and toxicologists in either drug and environmental wellbeing and fitness sciences.Content:
Chapter 1 easy Mitochondrial body structure in telephone Viability and dying (pages 1–35): Lech Wojtczak and Krzysztof Zablocki
Chapter 2 easy Molecular Biology of Mitochondrial Replication (pages 37–70): Immo E. Scheffler
Chapter three Drug?Associated Mitochondrial Toxicity (pages 71–126): Rhea Mehta, Katie Chan, Owen Lee, Shahrzad Tafazoli and Peter J. O'Brien
Chapter four Pharmacogenetics of Mitochondrial Drug Toxicity (pages 127–139): Neil Howell and Corinna Howell
Chapter five good points and Mechanisms of Drug?Induced Liver damage (pages 141–202): Dominique Pessayre, Alain Berson and Bernard Fromenty
Chapter 6 Cardiovascular Toxicity of Mitochondrial starting place (pages 203–234): Paulo J. Oliveira, Vilma A. Sardao and Kendall B. Wallace
Chapter 7 Skeletal Muscle and Mitochondrial Toxicity (pages 235–249): Timothy E. Johnson
Chapter eight Manifestations of Drug Toxicity on Mitochondria within the frightened approach (pages 251–271): Ian J. Reynolds
Chapter nine Lipoatrophy and different Manifestations of Antiretroviral Therapeutics (pages 273–290): Ulrich A. Walker
Chapter 10 Nephrotoxicity (pages 291–310): Alberto Ortiz, Alberto Tejedor and Carlos Caramelo
Chapter eleven Drug results in sufferers with Mitochondrial illnesses (pages 311–324): Eric A. Schon, Michio Hirano and Salvatore Dimauro
Chapter 12 Polarographic Oxygen Sensors, the Oxygraph, and High?Resolution Respirometry to evaluate Mitochondrial functionality (pages 325–352): Erich Gnaiger
Chapter thirteen Use of Oxygen?Sensitive Fluorescent Probes for the evaluate of Mitochondrial functionality (pages 353–371): James Hynes, Tom?s C. O'Riordan and Dmitri B. Papkovsky
Chapter 14 Mitochondrial disorder Assessed Quantitatively in actual Time by means of Measuring the Extracellular Flux of Oxygen and Protons (pages 373–382): David Ferrick, Min Wu, Amy speedy and Andy Neilson
Chapter 15 overview of Mitochondrial respiration advanced functionality in Vitro and in Vivo (pages 383–395): Mark A. Birch?Machin
Chapter sixteen OXPHOS complicated task Assays and Dipstick Immunoassays for overview of OXPHOS Protein degrees (pages 397–412): Sashi Nadanaciva
Chapter 17 Use of Fluorescent newshounds to degree Mitochondrial Membrane strength and the Mitochondrial Permeability Transition (pages 413–431): Anna?Liisa Nieminen, Venkat ok. Ramshesh and John J. Lemasters
Chapter 18 Compartmentation of Redox Signaling and keep an eye on: Discrimination of Oxidative pressure in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum (pages 433–461): Patrick J. Halvey, Jason M. Hansen, Lawrence H. Lash and Dean P. Jones
Chapter 19 Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening (pages 463–472): Edward E. McKee
Chapter 20 Mitochondrial Toxicity of Antiviral medicines: A problem to actual analysis (pages 473–491): Michel P. de Baar and Anthony de Ronde
Chapter 21 medical evaluate of Mitochondrial functionality through [13C]Methionine Exhalation (pages 493–506): Laura Milazzo
Chapter 22 review of Mitochondrial disorder by way of Microscopy (pages 507–538): Ingrid Pruimboom?Brees, Germaine Boucher, Amy Jakowski and Jeanne Wolfgang
Chapter 23 improvement of Animal types of Drug?Induced Mitochondrial Toxicity (pages 539–554): Urs A. Boelsterli and Yie Hou Lee
Chapter 24 Noninvasive evaluate of Mitochondrial functionality utilizing Nuclear Magnetic Resonance Spectroscopy (pages 555–574): Robert W. Wiseman and J. A. L. Jeneson
Chapter 25 focusing on Antioxidants to Mitochondria by means of Conjugation to Lipophilic Cations (pages 575–587): Michael P. Murphy