By Volker Bühler
The publication describes the homes, analytical tools and the purposes of alternative polyvinylpyrrolidone excipients (povidone, crospovidone, copovidone etc.) to be used in pharmaceutical arrangements. This crew of excipients is without doubt one of the most crucial excipients utilized in sleek expertise to supply medications. The e-book is meant for all folks operating within the learn, improvement and quality controls of gear. It supplies a survey of all purposes in strong, liquid and semisolid dosage kinds together with many drug formula examples and greater than six hundred references to the literature.
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Extra resources for Polyvinylpyrrolidone Excipients for Pharmaceuticals: Povidone, Crospovidone and Copovidone
2) Solution No. Rel. 3 Analytical methods for povidone Table 29. 5 Stability of the molecular weight in liquid dosage forms after sterilization with gamma radiation Unlike the powders, aqueous solutions of povidone are sensitive to gamma radiation. This was checked with povidone K 17 and povidone K 30. Table 29 presents the results of molecular weight measurements on povidone K 17 that was exposed, as the 10% aqueous solution, to radiation of different intensities. A clear increase in the average molecular weight and a broadening of the molecular weight distribution were found.
The formation of peroxides, free vinylpyrrolidone or turbity is no problem and the influence of the pH is negligible. 2 Product properties Table 26. Eur. Eur. 0 FTU (= Formazine Turbity Unit) Similar results were found with respective solutions of the low-molecular povidone Kollidon® 17 PF. If sodium bisulfite is to be used as an antioxidant in parenteral preparations, the legal situation in the respective country must be considered. 4 Stability of the molecular weight in liquid dosage forms after thermal sterilization and storage As the molecular weight determines many of the properties of povidone that affect its use, it is worth knowing that it is not changed by storage or heating.
5 g/l are taken, the complexed proportion of salicylic acid is less than 1% and can therefore be ignored. As all the pharmaceutically active substances, apart from tannin, that have been checked to date have shown complexation constants of less than 10 l/mol, the above example for salicylic acid can be applied to almost all drugs. Complexation is widely used in pharmaceutical technology (Table 21). 5 1 2 5 10 20 50 100 Povidone concentration, g/l Fig. 22. Curves of drug complexation by povidone against povidone concentration for different complexation constants, Kp Table 21.