Translational medicine : the future of therapy? by James Mittra, Christopher-Paul Milne

By James Mittra, Christopher-Paul Milne

This booklet brings jointly a number of educational, and practitioner views on translational medication (TM). It complements conceptual and useful knowing of the emergence and growth of the sector and its strength effect on uncomplicated examine, healing improvement, and institutional infrastructure. In acceptance of many of the implications TM has for public future health coverage and advertisement innovation, the e-book addresses the main systemic features of the sphere. The members discover the dynamic interactions and key demanding situations in translating new technological know-how into attainable remedies for the health facility, along with spotting the significance of social, advertisement, and regulatory environments as well as strong science.

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On appointment in May 2002, Zerhouni immediately undertook a wide-ranging review of NIH policy, including its support of/provision for clinical investigation, engaging at “grass roots” level to identify “roadblocks” to research and to formulate future policy priorities. The findings provided the basis for a policy known as The Roadmap. This initiative gave meaning and form to the term “translational” research and also became perhaps the defining feature of Zerhouni’s 6-year term as NIH director. Through the mechanism of “translational research,” the Roadmap sought to reform core components of the US biomedical research enterprise to reflect what he called the “new reality” of the post-genomic era [39].

As Lowy has noted, physicians base their claim to effectiveness on scientific knowledge, whilst biomedical scientists justify the cost of their research on its potential contribution to the improvement of health [3]. The two domains were bound together in uneasy partnership as clinical investigation and scientific research came to be seen as integral to medicine. Some stunning successes were realized, evidenced most strikingly in increasing life expectancy which, for example, in the United States rose by 30 years between 1900 and 2000.

It had long been a slippery term encompassing a range of diverse activities, from patient-centred research at the bedside, to lab-based research into © 2013 by Taylor & Francis Group, LLC 33 January 17, 2013 10:12 PSP Book - 9in x 6in 34 New Light Through an Old Window? the molecular basis of disease, to the clinical trial. It was here that the Nathan Committee ignited fiercest debate [28]. To the chagrin of many, Nathan defined clinical research very broadly, and included activities such as the development of new technologies and labbased studies of the mechanisms of human disease.

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